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UK-383367 is a novel procollagen C-proteinase inhibitor evaluated for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs). UK-383367 inhibits collagen deposition with IC50 of ~2 μM. UK-383367 is effective at penetrating human skin. Plasma protein binding values for UK 383367 in rat, dog and human are 95%, 93% and 94% respectively.
| Molecular Weight | 324.38 |
| Formula | C15H24N4O4 |
| CAS Number | 348622-88-8 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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