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UCB9608 

Cat. No. M28693

All AbMole products are for research use only, cannot be used for human consumption.

UCB9608  Structure

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Quality Control & Documentation
Biological Activity

UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent.

Chemical Information
Molecular Weight 410.47
Formula C20H26N8O2
CAS Number 1616413-96-7
Form Solid
Solubility (25°C) DMSO 65 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nana Dang, et al. J Heart Lung Transplant. Establishment of operational tolerance to sustain antitumor immunotherapy

[2] Yikui Li, et al. Cells. A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability

[3] James Reuberson, et al. J Med Chem. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo

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  Catalog
Abmole Inhibitor Catalog




Keywords: UCB9608  supplier, PI3K, inhibitors, activators

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