All AbMole products are for research use only, cannot be used for human consumption.
Ubenimex (Bestatin) is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N (Ki = 0.001 - 90 mM). Ubenimex inhibits enkephalin metabolism and leukotriene A4 hydrolase. Bestatin also inhibits tumor cell proliferation. Bestatin induced cell growth inhibition and phenotypic changes of HL-60 and HL-60R cell lines. In vitro, the upregulation of CD13/aminopeptidase N was found after 1 hr, however, the downregulation was observed after 3 hrs incubation with Ubenimex (Bestatin). On the other hand, the downregulation of CD15 and CD33 was observed after both one and 3 hrs incubation. Ubenimex may also be an effective anti-leukemic agent in vivo.
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Oct 30;40(10):1465-1471.
Pathogenic role leukotriene B4 in lung injury induced by lung-protective mechanical ventilation in rabbits
Ubenimex purchased from AbMole
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Nov 20;37(11):1523-1528.
Pathogenic role of leukotriene B4 in pulmonary microvascular endothelial cell hyper- permeability induced by one lung ventilation in rabbits
Ubenimex purchased from AbMole
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Source | Nan Fang Yi Ke Da Xue Xue Bao (2020 Oct), Figure 3, Ubenimex (Abmole Bioscience) |
| Method | oral gavage | |
| Cell Lines | Japanese white rabbits | |
| Concentrations | 8 mg/kg·d | |
| Incubation Time | 5 days | |
| Results | Compared with those in PM group, the rabbits in group BPM showed significantly reduced LTB4 production in the lungs (P < 0.05), up-regulated cAMP/ PKA and Rap1 signaling pathway activities (P < 0.05), and alleviated lung hyper-permeability and inflammation (P < 0.05). |
| Molecular Weight | 308.38 |
| Formula | C16H24N2O4 |
| CAS Number | 58970-76-6 |
| Solubility (25°C) | DMSO 3 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aminopeptidase Products |
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| Tosedostat
CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively. |
| Acebilustat
Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug. |
| TNP-470
TNP-470 (AGM-1470; NSC 642492) is a synthetic analog of fumagillin (or Fumagillol) and a methionine aminopeptidase-2 inhibitor. |
| L-Leucinol
L-Leucinol ((+)-Leucinol) is a potent, competitive leucine aminopeptidase inhibitor with Ki value of 17 μM. |
| Bestatin hydrochloride
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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