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U-46619 is a pGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U-46619 potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. U-46619 activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
| Molecular Weight | 350.5 |
| Formula | C21H34O4 |
| CAS Number | 56985-40-1 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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