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U0126 is a potent, non-ATP-competitive, selective inhibitor of MEK1 and MEK2 with IC50s of 72 nM and 58 nM, respectively.In addition, U0126 is an autophagy and mitophagy inhibitor and inhibits LPA-induced entosis.
Biochem Pharmacol. 2025 Jun 06; .
Involvement of ADAM17-dependent MUC1-CT activation in TGF-β-induced EZH2 expression in human lung fibroblasts and in ovalbumin-induced airway fibrosis in mice
U0126 purchased from AbMole
| Molecular Weight | 380.49 |
| Formula | C18H16N6S2 |
| CAS Number | 109511-58-2 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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