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Tyrphostin AG 1112 is a potent CK II inhibitor. In addition, Tyrphostin AG 1112 inhibited p210bcr-abl tyrosine kinase with IC50 values of 2 μM, 15 μM, and 20 μM against p210bcr-abl, EGFR, and PDGFR kinases, respectively, in cells.
| Molecular Weight | 274.28 |
| Formula | C15H10N6 |
| CAS Number | 153150-84-6 |
| Solubility (25°C) | DMSO: soluble |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver
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| PF-4800567
PF-4800567 is a selective, ATP competitive casein kinase 1ε inhibitor with IC50 values of 32 and 711 nM for CK1ε and CK1δ respectively. |
| D4476
D4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) with IC50 of 0.3 µM and 0.5 µM, respectively. |
| TTP 22
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM. |
| TBB
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
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