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TXA6101

Cat. No. M21096

All AbMole products are for research use only, cannot be used for human consumption.

TXA6101  Structure

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Quality Control & Documentation
Biological Activity

TXA6101 is a filamentous temperature-sensitive mutant Z (FtsZ) protein inhibitor. TXA6101 has an antibacterial activity MIC value of 1 μg/mL against MRSA isolates expressing either G193D or G196S mutant FtsZ, retaining significant activity against the TXA707-resistant FtsZ mutant. It is being developed for use against Gram-negative bacteria.

Chemical Information
Molecular Weight 477.18
Formula C18H10BrF5N2O3
CAS Number 1459695-66-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jesus D Rosado-Lugo, et al. J Antibiot (Tokyo). Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors

[2] Junso Fujita, et al. ACS Chem Biol. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

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Keywords: TXA6101 supplier, inhibitors, activators

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