Free shipping on all orders over $ 500

Tubulin polymerization-IN-42

Cat. No. M41521

All AbMole products are for research use only, cannot be used for human consumption.

Tubulin polymerization-IN-42 Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

Tubulin polymerization-IN-42, an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity.

Chemical Information
Molecular Weight 379.41
Formula C22H21NO5
CAS Number 2640220-51-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tessy Thomas Maliekal et al. Front Immunol. Tubulin Isotypes: Emerging Roles in Defining Cancer Stem Cell Niche

[2] Zhewang Lin et al. Science. TTC5 mediates autoregulation of tubulin via mRNA degradation

[3] Ernesto José Cuenca-Zamora et al. Int J Mol Sci. Tubulin in Platelets: When the Shape Matters

[4] Christopher H S Aylett et al. Subcell Biochem. The Tubulin Superfamily in Archaea

[5] Ramandeep Kaur et al. Eur J Med Chem. Recent developments in tubulin polymerization inhibitors: An overview

Related Microtubule Products
ABT-751

ABT-751 is an orally bioavailable tubulin inhibitor with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively.

Vincristine sulfate

Vincristine, formally known as leurocristine, is a mitotic inhibitor used in cancer chemotherapy.

Docetaxel

Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.

Paclitaxel

Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM.

Fosbretabulin disodium

Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Tubulin polymerization-IN-42 supplier, Microtubule, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.