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TTP-8307 

Cat. No. M30963

All AbMole products are for research use only, cannot be used for human consumption.

TTP-8307  Structure
Size Price Availability Quantity
5mg USD 285 In stock
10mg USD 445 In stock
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Quality Control & Documentation
Biological Activity

TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP).

Chemical Information
Molecular Weight 436.48
Formula C27H21FN4O
CAS Number 950225-08-8
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Brett L Roberts, et al. Antiviral Res. Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds

[2] Lucian Albulescu, et al. Antiviral Res. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307

[3] Heléne Norder, et al. Antiviral Res. Picornavirus non-structural proteins as targets for new anti-virals with broad activity

[4] Leire Aguado, et al. J Med Chem. 9-Arylpurines as a novel class of enterovirus inhibitors

[5] Armando M De Palma, et al. Antimicrob Agents Chemother. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307

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Keywords: TTP-8307  supplier, Anti-infection, inhibitors, activators

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