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TTA-A2 

Cat. No. M30967

All AbMole products are for research use only, cannot be used for human consumption.

TTA-A2  Structure

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Quality Control & Documentation
Biological Activity

TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.

Chemical Information
Molecular Weight 378.39
Formula C20H21F3N2O2
CAS Number 953778-63-7
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Neema Kumari, et al. Cancer Drug Resist. Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

[2] Sascha R A Alles, et al. Front Pain Res (Lausanne). Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

[3] Neema Kumari, et al. J Biomol Struct Dyn. Antagonistic interaction between TTA-A2 and paclitaxel for anti-cancer effects by complex formation with T-type calcium channel

[4] Neema Kumari, et al. Life Sci. T-type calcium channel antagonist, TTA-A2 exhibits anti-cancer properties in 3D spheroids of A549, a lung adenocarcinoma cell line

[5] Magali Cazade, et al. Mol Pharmacol. Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2

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Keywords: TTA-A2  supplier, Calcium Channel, inhibitors, activators

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