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Troxacitabine is a nucleoside analog with potent anticancer activity. Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50 values range from 15-35 μM.
Troxacitabine has good responses in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days.
| Molecular Weight | 213.19 |
| Formula | C8H11N3O4 |
| CAS Number | 145918-75-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | 4°C, protect from light, dry |
| Related Nucleoside Antimetabolite/Analog Products |
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5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors. |
| N6-(2-Hydroxyethyl)adenosine
N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. |
| 5-Cyanouridine
5-Cyanouridine is a thymidine analog. |
| 5-Bromouridine
5-Bromouridine is a purine nucleoside analog, with broad antitumor activity rely on inhibition of DNA synthesis, induction of apoptosis, etc. |
| CNDAC hydrochloride
CNDAC hydrochloride is a metabolite of Sapacitabine, and it is a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis. |
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