All AbMole products are for research use only, cannot be used for human consumption.
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.
| Molecular Weight | 416.35 |
| Formula | C20H15F3N4O3 |
| CAS Number | 147059-72-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL (ultrasonic and adjust pH to 4 with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Trovafloxacin
[2] J R Azanza, et al. Rev Med Univ Navarra. [Trovafloxacin]
[3] A A Alghasham, et al. Ann Pharmacother. Trovafloxacin: a new fluoroquinolone
[4] K W Garey, et al. Pharmacotherapy. Trovafloxacin: an overview
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