All AbMole products are for research use only, cannot be used for human consumption.
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases bile acid conjugation, transport, and excretion, thereby protecting the liver from the harmful effects of bile accumulation, leading to considerable interest in FXR as a therapeutic target for the treatment of cholestasis and nonalcoholic steatohepatitis.
Eur J Pharmacol. 2024 Mar 5;966:176334.
Farnesoid X receptor agonist tropifexor detoxifies ammonia by regulating the glutamine metabolism and urea cycles in cholestatic livers
Tropifexor purchased from AbMole
Liver Int. 2021 Sep;41(9):2117-2131.
A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis
Tropifexor purchased from AbMole
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Source | Liver Int (2021). Figure 4. Tropifexor (Abmole Bioscience) |
| Method | gavage | |
| Cell Lines | Guangxi Bama mini-pigs | |
| Concentrations | 1.06 μg/kg | |
| Incubation Time | a day since 2 d | |
| Results | RT-qPCR analysis showed that the mRNA levels of the cholangiocyte markers KRT7, KRT19 and MMP7 were reduced in BDL + TXR piglets compared with BDL piglets. Western blot analysis showed that the expression of CK19 protein was significantly decreased in the liver samples of BDL + TXR compared with that of BDL piglets. |
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Source | Liver Int (2021). Figure 3. Tropifexor (Abmole Bioscience) |
| Method | gavage | |
| Cell Lines | Guangxi Bama mini-pigs | |
| Concentrations | 1.06 μg/kg | |
| Incubation Time | a day since 2 d | |
| Results | Consistently, western blot analysis showed that BDL significantly increased the protein levels of α-SMA and collagen I in the liver samples of BDL piglets but not in that of BDL + TXR piglets |
| Molecular Weight | 603.58 |
| Formula | C29H25F4N3O5S |
| CAS Number | 1383816-29-2 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Farnesoid X Receptor Products |
|---|
| GW4064
GW4064 is a selective, non-steroidal agonist of the orphan nuclear receptor FXR with EC50 of 15 nM. |
| WAY-362450 (Turofexorate isopropyl)
WAY-362450 (Turofexorate isopropyl; XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM. |
| Chenodeoxycholic acid
Chenodeoxycholic acid is an epimer of ursodeoxycholic acid, which inhibits the production of cholesterol in the liver and absorption in the intestines. |
| Obeticholic Acid (INT-747)
Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH). |
| Sevelamer HCl
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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