All AbMole products are for research use only, cannot be used for human consumption.
Triolex is an ERK as well as nuclear factor κB inhibitor inhibitor that selectively inhibits the inflammatory ERK signaling pathway and may reduce neuroinflammation by inhibiting inflammation-driven insulin resistance and major pathological inflammatory cascades. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim attenuates NF-κB phosphorylation, but not influences IκB phosphorylation of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages. Bezisterim (100 nM, overnight) partially blocks the activation of IKK, JNK, p38, and ERK of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis.
| Molecular Weight | 330.47 |
| Formula | C21H30O3 |
| CAS Number | 1001100-69-1 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, dry, sealed |
[1] Anbalagan Anithasri. Biochem Mol Biol Educ. An ode on the odyssey of lipids
[2] Rae Varcoe. Ann Intern Med. A Triolet for Newly Hatched Docs
[3] Lucie Appy et al. Molecules. Synthetic Strategies for Dinucleotides Synthesis
[4] Jan Mauer et al. Nature. Reversible methylation of m6Am in the 5' cap controls mRNA stability
[5] F Dessertenne et al. Ann Med Interne (Paris). [Triolet's bruit]
| Related NF-κB Products |
|---|
| QNZ
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Methylthiouracil
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
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