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Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia.
| Molecular Weight | 563.56 |
| Formula | C25H33N5O10 |
| CAS Number | 82952-64-5 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Related Antifolate Products |
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| Pemetrexed disodium
Pemetrexed is a novel antifolic acid antimetabolic compound with K I of 1.3 nM, 7.2 nM, and 65 nM for TS, DHFR, and GARFT, respectively. |
| Methotrexate
Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| Folinic acid calcium salt
Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
| Sulfamethazine
Sulfamethazine is a sulfonamide antibacterial. |
| Pyrimethamine
Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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