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Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
| Molecular Weight | 75.11 |
| Formula | C3H9NO |
| CAS Number | 1184-78-7 |
| Solubility (25°C) | Water 90 mg/mL DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Yingqian Zhu, et al. APMIS. Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide
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