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Trigonelline, an alkaloid with potential antidiabetic activity, is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells. Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells.
| Molecular Weight | 137.14 |
| Formula | C7H7NO2 |
| CAS Number | 535-83-1 |
| Solubility (25°C) | Water 100 mg/mL DMSO 6 mg/mL (May need ultrasonic) |
| Storage | 4°C, protect from light |
[1] Minji Choi, et al. Phytother Res. Trigonelline induces browning in 3T3-L1 white adipocytes
[4] Iziar A Ludwig, et al. Food Funct. Coffee: biochemistry and potential impact on health
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 2'-Deoxyinosine
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| Ribitol
Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose. |
| Glycodeoxycholic Acid
Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. |
| Glycolithocholic acid
Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC). |
| 4-Aminohippuric Acid
4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow. |
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