All AbMole products are for research use only, cannot be used for human consumption.
Triacsin C (WS 1228A) is a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor. Triacsin C inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively.
Triacsin C induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice. Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases. Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice.
| Molecular Weight | 207.27 |
| Formula | C11H17N3O |
| CAS Number | 76896-80-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 3 mg/mL |
| Storage | -20°C, dry, sealed |
[1] Hagan, et al. Eur J Pharmacol. Stimulation of 5-HT1B receptors causes hypothermia in the rat.
| Related Parasite Products |
|---|
| Praziquantel
Praziquantel (Biltricide) is an anthelmintic effective against flatworms. |
| Amprolium hydrochloride
Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake. |
| Amprolium
Amprolium is a coccidiostat used in poultry. |
| Broxyquinoline
Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes. |
| Clopidol
Clopidol is an antiprotozoal agent. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
