All AbMole products are for research use only, cannot be used for human consumption.
TPPU is a potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). TPPU inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. TPPU exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.
| Molecular Weight | 359.34 |
| Formula | C16H20F3N3O3 |
| CAS Number | 1222780-33-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 35.93 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Epoxide Hydrolase Products |
|---|
| Pentyl Chloroformate
Certain substituted caprolactam carbonates and ethers, compound compositions containing them and their use in the study of tumors. |
| AUDA
AUDA is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. |
| Valpromide
Valpromide (VPD) is a derivative of valproic acid (VPA) and is used as an antiepileptic drug. |
| EC5026
EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble inhibitor of Epoxide Hydrolase (sEH). EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. |
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Products are for research use only. Not for human use. We do not sell to patients.
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