Free shipping on all orders over $ 500

TPCK

Cat. No. M30043

All AbMole products are for research use only, cannot be used for human consumption.

TPCK Structure
Synonym:

L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK

Size Price Availability Quantity
5mg USD 21 In stock
10mg USD 32 In stock
25mg USD 45 In stock
50mg USD 65 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium.

Chemical Information
Molecular Weight 351.85
Formula C17H18ClNO3S
CAS Number 402-71-1
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jay Trivedi, et al. Biochem Biophys Res Commun. N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) inhibits HIV-1 by suppressing the activity of viral protease

[2] Rana Anjum, et al. FEBS Lett. TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues

[3] Z Fabian, et al. Biochem Biophys Res Commun. TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase

[4] Z Fabian, et al. Apoptosis. TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells

[5] E Schmitt, et al. Biochem Cell Biol. The Bcl-xL and Bax-alpha control points: modulation of apoptosis induced by cancer chemotherapy and relation to TPCK-sensitive protease and caspase activation

Related Serine/Threonine Protease Products
PMSF

PMSF is an irreversible serine/cysteine protease inhibitor. PMSF is commonly used in the preparation of cell lysates.

Aprotinin

Aprotinin is a small protein serine protease inhibitor which is used to reduce perioperative blood loss and transfusion.

AEBSF HCl

AEBSF HCl is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

Nafamostat Mesylate

Nafamostat Mesylate is a synthetic serine protease inhibitor with concomitant anticoagulant activity.

UKI-1

UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator, which inhibits the invasive capacity of carcinoma cells with a Ki of 0.41 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: TPCK, L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK supplier, Serine/Threonine Protease, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.