All AbMole products are for research use only, cannot be used for human consumption.
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.
AAPS PharmSciTech. 2020 Nov 2;21(8):298.
Targeted and Combined TPCA-1-Gold Nanocage Therapy for In Vivo Treatment of Inflammatory Arthritis
TPCA-1 purchased from AbMole
Pharmaceutics. 2019 Mar 25;11(3).
Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation.
TPCA-1 purchased from AbMole
 |
Source | AAPS PharmSciTech (2020 Nov), Figure 3, TPCA-1 (Abmole Bioscience Inc. Houston, TX, USA) |
| Method | TPCA-1-treated | |
| Cell Lines | mice | |
| Concentrations | 0.016 mg/kg | |
| Incubation Time | 6 days | |
| Results | AuNCs/T/P and HA-AuNCs/T/P treatment significantly reduced the clinical arthritis score and swelling of the hind paws compared with untreated and TPCA-1-treated mice. |
| Molecular Weight | 279.29 |
| Formula | C12H10FN3O2S |
| CAS Number | 507475-17-4 |
| Solubility (25°C) | DMSO 36 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IκB/IKK Products |
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BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| SC-514
SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| BMS-345541 hydrochloride
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). BMS-345541 binds at an allosteric site of IKK. |
| Bardoxolone Methyl
Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
| Bay 11-7085
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
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