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Toyocamycin is a adenosine analog; antifungal antibiotic. Toyocamycin (Vengicide) inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Toyocamycin (Vengicide) also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines. Toyocamycin specifically inhibits CDK9.
| Molecular Weight | 291.26 |
| Formula | C12H13N5O4 |
| CAS Number | 606-58-6 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, dry, sealed |
[3] Nishioka H, et al. J Antibiot (Tokyo). Inhibition of phosphatidylinositol kinase by toyocamycin.
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