All AbMole products are for research use only, cannot be used for human consumption.
Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM. Torin 1 shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1 induces autophagy in HeLa cells. Torin 1 is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice. In a recent study, it is reported Torin 1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.
Commun Biol. 2023 Apr 3;6(1):361.
WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis
Torin 1 purchased from AbMole
Cell Cycle. 2022 Sep 19;1-23.
Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence and late clinical metastasis in a Beclin-1-dependent manner.
Torin 1 purchased from AbMole
| Molecular Weight | 607.62 |
| Formula | C35H28F3N5O2 |
| CAS Number | 1222998-36-8 |
| Solubility (25°C) | DMSO ~2 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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