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Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity.
| Molecular Weight | 421.45 |
| Formula | C23H23N3O5 |
| CAS Number | 123948-87-8 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] S Ackermann, et al. Int J Gynecol Cancer. Topotecan in cervical cancer
[5] D Ormrod, et al. Drugs. Topotecan: a review of its efficacy in small cell lung cancer
| Related Topoisomerase Products |
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Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
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Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| Topotecan hydrochloride
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
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