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Topiroxostat (FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM. Topiroxostat (FYX-051) exhibited competitive-type inhibition with a Ki value of 5.7 × 10-9 M of native XO.
In vivo: In this hyperuricemic model, Topiroxostat in the dose range of 0.03 to 1 mg/kg caused a dose-dependent decrease in serum urate levels with an extremely low ED50 of 0.15 mg/kg, evaluated at 1 h after oral administration.
| Molecular Weight | 248.24 |
| Formula | C13H8N6 |
| CAS Number | 577778-58-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Xanthine Oxidase Products |
|---|
| Febuxostat (TEI-6720)
Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. |
| Allopurinol
Allopurinol is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. |
| Allopurinol Sodium
Allopurinol Sodium is a xanthine oxidase inhibitor and a structural isomer of hypoxanthine with an IC50 of 7.82 ± 0.12 μM, which inhibits the conversion of xanthine to uric acid and increases the reuse of hypoxanthine and xanthine in nucleic acid synthesis, thereby reducing serum and urinary uric acid levels, and can be used in gout-related studies. |
| Broussoflavonol F
Broussoflavonol F has xanthine oxidase inhibitory activity. |
| Vanillic acid
Vanillic acid inhibits NF-κB activation. Vanillic acid has anti-inflammatory, antibacterial, and chemopreventive effects. |
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