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Tonapofylline

Cat. No. M29942

All AbMole products are for research use only, cannot be used for human consumption.

Tonapofylline Structure
Synonym:

BG 9928

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Quality Control & Documentation
Biological Activity

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.

Chemical Information
Molecular Weight 416.51
Formula C22H32N4O4
CAS Number 340021-17-2
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Z Li, et al. Int J Clin Pharmacol Ther. Pharmacokinetics and pharmacodynamics of tonapofylline in subjects with severe renal impairment and in elderly subjects

[2] Zhaoyang Li, et al. J Clin Pharmacol. Clinical pharmacokinetics of tonapofylline: evaluation of dose proportionality, oral bioavailability, and gender and food effects in healthy human subjects

[3] Christopher R Ensor, et al. Expert Opin Pharmacother. Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment of heart failure

[4] Alan Gill, et al. Am J Nephrol. Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against cisplatin-induced acute kidney injury in rats

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Keywords: Tonapofylline, BG 9928 supplier, Adenosine Receptor, inhibitors, activators

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