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Tonabersat

Cat. No. M8507

All AbMole products are for research use only, cannot be used for human consumption.

Tonabersat Structure
Synonym:

SB-220453

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Quality Control & Documentation
Biological Activity

Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.

Chemical Information
Molecular Weight 391.82
Formula C20H19ClFNO4
CAS Number 175013-84-0
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Heather Lyon, et al. Tonabersat Inhibits Connexin43 Hemichannel Opening and Inflammasome Activation in an In Vitro Retinal Epithelial Cell Model of Diabetic Retinopathy

[2] Qing Chen, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

[3] Yue Cao, et al. Tonabersat for migraine prophylaxis: a systematic review

[4] S D Silberstein. Tonabersat, a novel gap-junction modulator for the prevention of migraine

[5] P L Durham, et al. Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine

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  Catalog
Abmole Inhibitor Catalog




Keywords: Tonabersat, SB-220453 supplier, inhibitors, activators

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