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TOFA

Cat. No. M8819

All AbMole products are for research use only, cannot be used for human consumption.

TOFA Structure
Synonym:

RMI14514; MDL14514

Size Price Availability Quantity
1mg USD 25 In stock
5mg USD 38 In stock
10mg USD 65 In stock
25mg USD 130 In stock
50mg USD 240 In stock
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Quality Control & Documentation
Biological Activity

TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.

Chemical Information
Molecular Weight 324.45
Formula C19H32O4
CAS Number 54857-86-2
Solubility (25°C) DMSO 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Andreas Kerschbaumer, et al. Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a systematic literature research

[2] Fang-Fang Zhu, et al. Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma

[3] Dejiao He, et al. TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway

[4] Shu Li, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo

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Keywords: TOFA, RMI14514; MDL14514 supplier, inhibitors, activators

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