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TMN 355

Cat. No. M7414

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TMN 355 Structure
Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 150 In stock
25mg USD 300 In stock
50mg USD 450 In stock
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Quality Control & Documentation
Biological Activity

TMN 355 is a potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models 8-week-old male C57/BL6 MCD diet mice
Formulation vehicle (DMSO)
Dosages 10 mg/kg or 20 mg/kg
Administration intraperitoneally
Chemical Information
Molecular Weight 380.8
Formula C21H14ClFN2O2
CAS Number 1186372-20-2
Solubility (25°C) DMSO 15.23 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tian Zhang, et al. Front Cell Dev Biol . Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner

[2] Surya Ramachandran, et al. Cardiovasc Diabetol . Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus

[3] Penning, et al. J Med Chem. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

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Keywords: TMN 355 supplier, Cyclophilin, inhibitors, activators

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