All AbMole products are for research use only, cannot be used for human consumption.
TMI 1 is a adam 17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.
Food Chem Toxicol. 2022 Sep 24;169:113441.
Melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting ADAM17/TNF-α axis
TMI 1 purchased from AbMole
| Molecular Weight | 398.49 |
| Formula | C17H22N2O5S2 |
| CAS Number | 287403-39-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 39.85 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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