All AbMole products are for research use only, cannot be used for human consumption.
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Adult mongrel dogs |
| Formulation | In saline |
| Dosages | ~500 mg/kg |
| Administration | I.P. |
| Molecular Weight | 440.6 |
| Formula | C22H36N2O5S |
| CAS Number | 144494-65-5 |
| Form | Solid |
| Solubility (25°C) | 1M HCl: 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lukasz Szarpak, et al. Tirofiban in emergency conditions
[3] Scott D Nei, et al. Tirofiban in Suspected Left Ventricular Assist Device Pump Thrombosis
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