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Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.
| Molecular Weight | 279.12 |
| Formula | C9H11ClN4O2.HCl |
| CAS Number | 183204-72-0 |
| Solubility (25°C) | Water: 12 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Robert J Mayer, et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer
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