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Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model. Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells.
| Molecular Weight | 750.25 |
| Formula | C34H32Cl2N4O4Sn |
| CAS Number | 14325-05-4 |
| Form | Solid |
| Solubility (25°C) | 1eq. NaOH 18 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Heme oxygenase Products |
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| Hemin chloride
Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis. |
| Zinc Protoporphyrin
Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. |
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