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Timosaponin BII is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities. Timosaponin BII can inhibit the up-regulation of BACE1 and reduced the over-production of β-CTF and Aβ in rat retina, which was induced by FeCl.
Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time.
| Molecular Weight | 921.07 |
| Formula | C45H76O19 |
| CAS Number | 136656-07-0 |
| Solubility (25°C) | Water 93 mg/mL DMSO 93 mg/mL |
| Storage | -20°C, dry, sealed |
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