All AbMole products are for research use only, cannot be used for human consumption.
In vitro: Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. In vitro, it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM. In vivo: The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice.
Antiviral Res. 2024 Apr 18.
An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity
Thiomyristoyl purchased from AbMole
J Clin Invest. 2023 Jun 15;133(12):e158978.
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
Thiomyristoyl purchased from AbMole
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Source | Mol Med Rep (2015). Figure 2. Thiomyristoyl |
| Method | Weatern Blot | |
| Cell Lines | HEK293T cells | |
| Concentrations | 200 μM | |
| Incubation Time | 24 h | |
| Results | TNFα from the cells treated with the four Sirt6 inhibitors had increased fluorescent labelling (and thus increased fatty acylation levels) compared to TNFα from the control cells, suggesting that these thiomyristoyl peptides could inhibit SIRT6 in cells. |
| Cell Experiment | |
|---|---|
| Cell lines | breast cancer cell lines MCF-7 |
| Preparation method | Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. |
| Concentrations | 1, 5, 10, 25, 50 μM |
| Incubation time | 6 h |
| Animal Experiment | |
|---|---|
| Animal models | Mouse xenograft model |
| Formulation | DMSO |
| Dosages | 1.5 mg/50 μL (IP); 0.75 mg/50 μL (IT) |
| Administration | intraperitoneal (IP) or intra-tumor (IT) injections |
| Molecular Weight | 581.85 |
| Formula | C34H51N3O3S |
| CAS Number | 1429749-41-6 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Sirtuin Products |
|---|
| Selisistat
Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| SRT1720 Hydrochloride
SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| Resveratrol
Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. |
| Balsalazide disodium
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis. |
| Sirtinol
Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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