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Thapsigargin is a potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Thapsigargin causes ER stress; Thapsigargin can be used to induce autophagy in mammalian cells. Thapsigargin inhibits cell growth in a time-dependent manner, especially in the HepG2 cells, for which 64% cell growth is inhibited at 96 h compared with 45% in the HepG2.2.15 cells (P<0.001).
J Food Sci. 2023 Jan;88(1):523-536.
Effect of Flammulina velutipes polysaccharides on endoplasmic reticulum stress-mediated apoptosis by activating PLC–IP3 pathway in HepG2 cells
Thapsigargin purchased from AbMole
| Molecular Weight | 650.76 |
| Formula | C34H50O12 |
| CAS Number | 67526-95-8 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Geiszt M, et al. Biochem J. Thapsigargin inhibits Ca2+ entry into human neutrophil granulocytes.
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