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TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
| Molecular Weight | 527.79 |
| Formula | C20H21Cl3N8O3 |
| CAS Number | 2253744-57-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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