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TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM).
| Molecular Weight | 256.30 |
| Formula | C15H16N2O2 |
| CAS Number | 2196203-96-8 |
| Solubility (25°C) | DMSO 51 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Eftiola Pojani, et al. Curr Med Chem. Selective Inhibitors of Histone Deacetylase 10 (HDAC-10)
[5] T Matsumura, et al. Rinsho Shinkeigaku. [A case of idiopathic spinal cord herniation]
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