All AbMole products are for research use only, cannot be used for human consumption.
TGN 020 is a aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
| Cell Experiment | |
|---|---|
| Cell lines | TR-MUL5 |
| Preparation method | Then, volumetric changes of TR-MUL5 and intracellular levels of ROS were determined using flow cytometry analysis of ethidium fluorescence in the presence or absence of TGN-020 (100 nM) or bevacizumab overnight under physiological and high glucose conditions. |
| Concentrations | 100 nM |
| Incubation time | Over night |
| Animal Experiment | |
|---|---|
| Animal models | Sprague-Dawley rats |
| Formulation | 10% DMSO |
| Dosages | 100 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 206.22 |
| Formula | C8H6N4OS |
| CAS Number | 51987-99-6 |
| Solubility (25°C) | 1eq. HCl 2.06 mg/mL (with gentle warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related AQP Products |
|---|
| Bacopaside II
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis. |
| Aristolactam I
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. |
| TC AQP1 1
TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC50 of 8 μM. |
| AqF026
AqF026 is an agonist of the water channel aquaporin-1. AqF026 potentiated the channel activity of human AQP1 by >20% but had no effect on channel activity of AQP4. AqF026 enhanced the osmotic transport of water across the peritoneal membrane but did not affect the osmotic gradient, the transport of small solutes, or the localization and expression of AQP1 on the plasma membrane in a mouse model of peritoneal dialysis. |
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