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TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. TG4-155 crosses the blood brain barrier, and has no antagonistic effects on EP4 signaling, and displays neuroprotective effects in a pilocarpine-induced status epilepticus (SE) seizure model. TG4-155 significantly reduces neurodegeneration in a mouse model of status epilepticus, induced by pilocarpine.
| Molecular Weight | 394.46 |
| Formula | C23H26N2O4 |
| CAS Number | 1164462-05-8 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ganesh T. J Med Chem. Prostanoid receptor EP2 as a therapeutic target.
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