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TFCA is a Liver X receptor α (LXRα) antagonist that reduces lipid accumulation and fatty liver in mice. Apparently TFCA binds to the LXRα ligand binding domain and induces interaction with NCoR corepressor.
| Molecular Weight | 351.32 |
| Formula | C18H16F3NO3 |
| CAS Number | 895700-18-2 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Liver X Receptor Products |
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GW3965 hydrochloride is a selective, orally active non-steroidal synthetic liver X receptor (LXR) agonist. |
| T0901317
T0901317 is a potent and selective agonist for both LXRα and LXRβ with an EC50 of 20~50 nM. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. |
| SR9243
SR9243 is a potent and selective LXR inverse agonist. |
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LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier. |
| GSK2033
GSK2033 is a potent LXR antagonist. |
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