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Tetracycline hydrochloride is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic. Tetracycline binds to the 30S subunit of microbial ribosomes. Tetracycline inhibits protein synthesis by blocking the attachment of charged aminoacyl-tRNA. Thus tetracycline prevents introduction of new amino acids to the nascent peptide chain. The action is usually inhibitory and reversible upon withdrawal of the drug. Resistance to the tetracycline results from changes in permeability of the microbial cell envelope. In susceptible cells, the tetracycline is concentrated from the environment and does not readily leave the cell. Tetracycline hydrochloride is used in the treatment of bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others.
| Molecular Weight | 480.9 |
| Formula | C22H24N2O8.HCl |
| CAS Number | 64-75-5 |
| Solubility (25°C) | Water 50 mg/mL DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Antibiotic Products |
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| Kanamycin sulfate
Kanamycin sulfate is an aminoglycoside antibiotic that acts as a bacteriostatic agent by binding to the bacterial 30S ribosome. |
| Marbofloxacin
Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group which inhibiting bacterial DNA replication. |
| Linezolid
Linezolid (PNU-100766) is a synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. |
| Daptomycin
Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. |
| Sulfadimethoxine
Sulfadimethoxine (trade name Di-Methox, Albon) is a sulfonamide antibiotic. |
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