All AbMole products are for research use only, cannot be used for human consumption.
Terfenadine is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine is an antihistamine compound that is normally fully metabolized in the liver by the cytochrome P450 CYP3A4 subtype enzyme into the active form fexofenadine. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
| Molecular Weight | 471.67 |
| Formula | C32H41NO2 |
| CAS Number | 50679-08-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 48 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mayra Delgado-Ramrez, et al. Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels
[2] D W Aaronson. Effects of terfenadine on psychomotor performance. An overview
[3] J Soto, et al. Terfenadine-induced tremor
[4] R Jankowski, et al. Effect of terfenadine on nasal provocation
[5] H C Masheter. Terfenadine. The first nonsedating antihistamine
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