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Tenapanor (AZD1722) hydrochloride is a first-in-class, potent, orally active sodium/hydrogen exchange isomer 3 (NHE3) inhibitor that reduces intestinal phosphate absorption primarily by decreasing passive paracellular phosphate flux. Tenapanor hydrochloride reduces intestinal absorption of phosphate by reducing passive paracellular phosphate flux. Tenapanor hydrochloride is used in studies related to chronic renal insufficiency, hyperphosphatemia, constipation, and irritable bowel syndrome.
| Molecular Weight | 1217.97 |
| Formula | C50H68Cl6N8O10S2 |
| CAS Number | 1234365-97-9 |
| Form | Solid |
| Storage | 4°C, protect from light, dry, sealed |
| Related Na+/H+ Exchanger (NHE) Products |
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| Tenapanor
Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. |
| KR-32568
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 value of 0.23 μM. |
| Cariporide
Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. |
| EMD-87580
EMD-87580 is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. |
| FR183998 free base
FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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