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Tebipenem pivoxil (L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 ug/ml for human CYP isoforms. In mouse, rat, dog and monkey, TBPM-PI were absorbed quickly, and the bioavailability was (71.4, 59.1, 34.8 and 44.9%, respectively. There was no other tissue than the kidney, in which TBPM was highly distributed and remained for a long time. In addition, low penetration to the central nervous system was confirmed. The penetration ratio of TBPM to ELF, that is the ratio of ELF concentration to plasma concentration of TBPM, was 21.8 +/- 14.7%.
| Molecular Weight | 497.63 |
| Formula | C22H31N3O6S2 |
| CAS Number | 161715-24-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Varun Sodhi, et al. Tebipenem pivoxil hydrobromide-No PICC, no problem!
[2] Chao Tang, et al. Crystal structure of tebipenem pivoxil
[3] Akash Jain, et al. Tebipenem, the first oral carbapenem antibiotic
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