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TCS JNK 6o is a aTP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). TCS JNK 6o displays > 1000 fold selectivity over other kinases, including ERK2 and p38. TCS JNK 6o inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.
| Molecular Weight | 356.38 |
| Formula | C18H20N4O4 |
| CAS Number | 894804-07-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 35.64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related JNK Products |
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| JNK-IN-8
JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively. |
| SP600125
SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. |
| JNK Inhibitor IX
JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. |
| Cinobufagin
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| Polyphyllin-I
Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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