All AbMole products are for research use only, cannot be used for human consumption.
TCS 1102 is an effective antagonist of the dual orexin receptor. Research indicates that TCS 1102 blocks the ADL-orexin B-mediated locomotion. TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock. Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze.
| Molecular Weight | 470.59 |
| Formula | C27H26N4O2S |
| CAS Number | 916141-36-1 |
| Solubility (25°C) | 100 mM in DMSO 100 mM in Ethanol |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related OX Receptor Products |
|---|
| MK-6096
MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R. |
| Almorexant
Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. |
| SB408124
SB408124 (Tocris-1963) is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. |
| MK-3697
MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. |
| SB-334867 hydrochloride
SB-334867 hydrochloride is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
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Products are for research use only. Not for human use. We do not sell to patients.
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