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Tch-165 is a small molecule modulator of proteasome assembly that increases 20S levels and promotes 20S-mediated protein degradation.
| Molecular Weight | 595.73 |
| Formula | C39H37N3O3 |
| CAS Number | 1446350-60-2 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Evert Njomen, et al. Cell Chem Biol. Regulation of Autophagic Flux by the 20S Proteasome
[3] Evert Njomen, et al. Biochemistry. Small Molecule Modulation of Proteasome Assembly
| Related Proteasome Products |
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| CTP-518
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| ITMN-191
ITMN-191 (Danoprevir, RG7227) is a potent and orally active inhibitor of hepatitis C virus (HCV) NS3/4A serine protease with an IC50 of 1.6 nM. |
| MG132
MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM). MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132 is also a calpain inhibitor with IC50 of 1.2 μM. |
| IU1
IU1 is a reversible, small molecule inhibitor of deubiquitination by USP14 that demonstrates an IC50 value of 4-5 μM. |
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