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TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.
| Molecular Weight | 450.5 |
| Formula | C25H20F2N2O2S |
| CAS Number | 1257093-40-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 22.52 mg/mL (with gentle warming) |
| Storage | RT, dry |
| Related S1P Receptor Products |
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| FTY720 hydrochloride
Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
| BAF312
BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
| SEW2871
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. |
| CYM-5442
CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS). |
| JTE 013
JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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