All AbMole products are for research use only, cannot be used for human consumption.
BAY-549 (TC-S 7001) is a potent and highly selective, orally active ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively). BAY-549 (TC-S 7001) exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. BAY-549 (TC-S 7001) reduces blood pressure in normotensive and hypertensive rats.
BAY-549 (Azaindole 1) (0.03, 0.1, 0.3 mg/kg, i.v.) results in a dose-dependent and long-lasting decrease in blood pressure in anaesthetized normotensive rats. BAY-549 (3 and 10 mg/kg, p.o.) decreases blood pressure dose-dependently and persistently both in normotensive and hypertensive rats, and shows such effects even at 1 mg/kg in hypertensive rats. BAY-549 (0.1 and 0.3 mg/kg, i.v. bolus injections) causes decreased mean arterial blood pressure in a dose-related manner and only leads to a moderate and dose-independent increase in heart rate of anaesthetized dogs.
Int J Radiat Oncol Biol Phys. 2023 Oct 9;S0360-3016(23)07970-1.
Radiosensitization by hyperthermia critically depends on the time interval
TC-S 7001 purchased from AbMole
Nat Commun. 2022 Apr 28;13(1):2302.
TGS1 mediates 2, 2, 7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance
TC-S 7001 purchased from AbMole
Elife. 2022 Sep 26;11:e76721.
c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis
TC-S 7001 purchased from AbMole
| Molecular Weight | 402.79 |
| Formula | C18H13ClF2N6O |
| CAS Number | 867017-68-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ROCK Products |
|---|
| Y-27632 dihydrochloride
Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
| Thiazovivin
Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts. |
| Fasudil hydrochloride
Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM. |
| RKI-1447
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 6 nM, respectively. |
| GSK429286A
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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